RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
PTGS2
RNA ID
RNA Type
mRNA
Alteration Pattern
histone acetylation
Species
homo sapiens
Detection Methods
HDAC activity assay; ChIp assay; Reporter gene assay etc.
Target
NA
Pathway
NA
PubMed ID
Title
Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis
Year
2009
Function
"HDAC inhibitors and the overexpression of HATs restored cytokine-induced COX-2 mRNA and protein expression in F-IPF. The results demonstrate that epigenetic abnormality in the form of histone hypoacetylation is responsible for diminished COX-2 expression in IPF. Diminished cyclooxygenase 2 (COX-2) expression in fibroblasts, with a resultant defect in the production of the antifibrotic mediator prostaglandin E(2), promote pathogenesis of idiopathic pulmonary fibrosis (IPF)."